Nucl Med Mol Imaging.  2015 Sep;49(3):191-199. 10.1007/s13139-014-0316-y.

Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities

• Lee TK
• Kwon J
• Na KS
• Jeong HS
• Hwang H
• Oh PS
• Kim DH
• Jang KY
• Lim ST
• Sohn MH
• Jeong HJ

• KMID: 2052053
• DOI: http://doi.org/10.1007/s13139-014-0316-y

Abstract

PURPOSE
Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and the therapeutic effect was validated using different imaging methods.
METHODS
Male SD rats (n=18, 6 weeks old) were randomly assigned into three groups: Group 1 as control, Group 2 without any ligation of distal femoral artery, and Group 3 with temporary ligation of the distal femoral artery. RR1022 sarcoma cell lines were inoculated into thigh muscle. After 1week, CMH was injected into the proximal femoral artery. Different imaging modalities were performed during a 3-week follow-up.
RESULTS
The tumor size was significantly (P<0.001) decreased in both Group 2 and Group 3 (P<0.0010.001) after selective arterial embolization therapy. 18F-FDG-PET/CT revealed decreased intensity of 18F-FDG uptake in tumors. The accumulation status of 125I-CMH near the tumor was verified by gamma camera.
CONCLUSIONS
Appropriate selective arterial embolization therapy with CMH was.

Keyword

Selective arterial embolization Chitosan micro-hydrogel; Molecular imaging; Ultrasonography; Positron emission tomography (PET); Gamma camera; RR1022; Sarcoma; Rodent

MeSH Terms

Animals
Catheterization
Catheters
Cell Line
Chitosan*
Femoral Artery
Fluorodeoxyglucose F18
Follow-Up Studies
Gamma Cameras
Hindlimb*
Humans
Ligation
Male
Molecular Imaging
Rats
Rodentia*
Sarcoma*
Thigh
Ultrasonography
Chitosan
Fluorodeoxyglucose F18