Nucl Med Mol Imaging.
2010 Apr;44(1):33-38.
Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results
- Affiliations
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- 1Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University School of Medicine, Seoul, Korea.
- 2Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkawn University School of Medicine, #50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Korea. jynm.choi@samsung.com
- 3Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkawn University School of Medicine, Seoul, Korea.
Abstract
- PURPOSE
This study was conducted to compare 18F-FDG PET/CT and electromyography (EMG) mapping in patients with primary cervical dystonia (PCD) to find dystonic superficial cervical muscles. METHODS: Ten consecutive patients with PCD (M:F=5:5, age 44+/-13 years) whose dystonic posture was not relieved with conventional muscle relaxant therapy were included. Target cervical muscles for the comparison between 18FFDG PET/CT and EMG mapping were four representative superficial bilateral cervical muscles: splenius capitis muscle, sternocleidomstoid muscle, upper trapezius muscle, and leavator scapulae muscle. The diagnostic efficacy was compared between 18F-FDG PET/CT and EMG mapping using physical exam and measurement of rotation angle as the gold standard. RESULTS: Among 80 muscles evaluated, there were 21 (26%) dystonic superficial cervical muscles assessed with physical exam and motion analysis. The sensitivity, specificity, and accuracy for localizing dystonic muscles were 76, 92, and 88% for 18F-FDG PET/CT, and 95, 66, and 74% for EMG mapping, respectively. The sensitivity of EMG mapping was significantly higher than that of 18F-FDG PET/CT. In contrast, 18F-FDG PET/CT was significantly superior to EMG mapping for specificity and accuracy. CONCLUSIONS: 18F-FDG PET/CT is more specific and accurate than EMG mapping for finding superficial dystonic cervical muscles. The high sensitivity of EMG mapping suggests that 18F-FDG PET/CT and EMG mapping are complementary for finding dystonic superficial cervical muscles.
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