Tuberc Respir Dis.  1999 Aug;47(2):231-238. 10.4046/trd.1999.47.2.231.

The Resting and Exercise Related Oxygen Desaturation as The Associated Factor for Sleep Related Oxygen Desaturation in Patients with Chronic Obstructive Pulmonary Disease

• Shin CJ
• Lee KH
• Park HJ
• Shin KC
• Chung JH
• Lee HW

• KMID: 2050177
• DOI: http://doi.org/10.4046/trd.1999.47.2.231

Abstract

BACKGROUND: Nocturnal hypoxemia occurs in patients with chronic obstructive pulmonary disease(COPD) and the detection and treatment of nocturnal hypoxemia should be part of the management of COPD patients. We performed this study to evaluate the factors influencing to sleep related arterial oxygen desaturation(SaO2) in patients with COPD.
METHODS
Resting and exercise cardiopulmonary function test, polysomnography, and SaO2 during resting, exercise and sleep were measured in 12 patients with COPD.
RESULTS
The SaO2 fell twice as much during sleep as during maximal exercise(13.1 9.3% fall in nocturnal SaO2 vs. 6.4 3.3%, p<0.05). Fall in nocturnal SaO2 was well correlated with mean exercise SaO2(r=-0.78, p<0.05), minimum exercise SaO2(r=-0.90, p<0.01), and resting SaO2(r=-0.82, p<0.05). Lowest sleep SaO2 was well correlated with mean exercise SaO2(r=0.80, p<0.05), lowest exercise SaO2(r=0.90, p<0.01), and resting SaO2(r=0.84, p<0.05).
CONCLUSION
Resting and exercise SaO2 was well correlated with nocturnal SaO2, but exercise study add no additional information to predicting the nocturnal oxygen desaturation in patients with COPD.

Keyword

Chronic obstructive pulmonary disease; Sleep; Oxygen desaturation

MeSH Terms

Anoxia
Humans
Oxygen*
Polysomnography
Pulmonary Disease, Chronic Obstructive*
Oxygen