Tuberc Respir Dis.  1997 Apr;44(2):409-418. 10.4046/trd.1997.44.2.409.

The Effect of Corticosteroid on the Treatment of Endobronchial Tuberculosis

• Mo EK
• Kim HJ
• Choi JE
• Kim DG
• Park MJ
• Hyun IG
• Lee MK
• Jung KS

• KMID: 2050003
• DOI: http://doi.org/10.4046/trd.1997.44.2.409

Abstract

OBJECTIVE
Appropriate antituberculosis chemotherapy may not prevent occurrence or progression of tracheobronchial stenosis and obstruction in the patients with endobronchial tuberculosis. The effect of corticosteroid treatment combined with antituberculosis chemotherapy was inconclusive. We evaluated prospectively the effect of corticosteroid treatment.
METHODS
We diagnosed endobronchial tuberculosis by bronchoscopic examination and bronchial biopsy in the patients of tuberculosis within one month of antituberculosis chemotherapy. After randomization, we prescribed isoniazid, rifampin, ethambutol, and pyrazinamide with or without prednisolone 40 mg for 4 weeks. We carried out bronchoscopy in second month and ninth month of treatment.
RESULTS
Edematous endobronchial tuberculosis showed significant improvement of bronchial stenosis after corticosteroid treatment(p<0.05). Corticosteroid treatment did not have advantage of improvement of bronchial stenosis in the patients with infiltrative endobronchial tuberculosis.
CONCLUSION
Corticosteroid is effective in the treatment of bronchial stenosis when endobronchial tuberculosis is edematous type, in the early period of antituberculosis chemotherapy.

MeSH Terms

Biopsy
Bronchoscopy
Constriction, Pathologic
Drug Therapy
Ethambutol
Humans
Isoniazid
Prednisolone
Prospective Studies
Pyrazinamide
Random Allocation
Rifampin
Tuberculosis*
Ethambutol
Isoniazid
Prednisolone
Pyrazinamide
Rifampin