Chonnam Med J.  2007 Apr;43(1):13-18.

The Long-Term Clinical Effects of Elevated Troponin during Percutaneous Coronary Intervention to Predict Long-Term Clinical Outcome in Patients with Acute Coronary Syndrome

• Kim JH
• Jeong MH
• Hong YJ
• Moon JY
• Ahn YK
• Cho JG
• Park JC
• Kang JC

Abstract

The purpose of the study was to evaluate the effects of myocardial injury during percutaneous coronary intervention (PCI) on the long-term clinical outcome in patients with acute coronary syndrome (ACS) using cardiac troponin. Four hundred twenty four patients (61+/-10 year-old, 316 male) who underwent successful PCI with ACS, serum creatinine kinase isoenzyme MB (CK-MB), cardiac troponin T (cTnT) and I (cTnI) were measured before and at 6, 12, 24 hours after PCI. Patients were divided into two groups: Group I, elevated cTn and Group II, normal cTn after PCI. Major advanced cardiac events (MACE) were compared during 12-month clinical follow-up between both groups. Stenting was performed in 261 patients (62%) and ballooning in 163 patients (38%). The level of CK-MB was elevated in 89 patients (21%), cTnT in 118 patients (28%) and cTnI in 99 patients (23%) after PCI. MACE occurred in 47 patients (29%; revascularization in 42, acute myocardial infarction in 1, death in 4 patients) of Group I and in 39 patients (15%; revascularization in 37, acute myocardial infarction in 2 patients) of Group II (p<0.005) during 12-month clinical follow-up. The elevated cTn during PCI in patients with ACS is related to adverse effects on long-term prognosis.

Keyword

Coronary disease; Myocardium; Myoglobin; Angioplasty; Prognosis

MeSH Terms

Acute Coronary Syndrome*
Angioplasty
Coronary Disease
Creatinine
Follow-Up Studies
Humans
Myocardial Infarction
Myocardium
Myoglobin
Percutaneous Coronary Intervention*
Phosphotransferases
Prognosis
Stents
Troponin T
Troponin*
Creatinine
Myoglobin
Phosphotransferases
Troponin
Troponin T