Allergy.
1994 Sep;14(3):329-332.
The variation of theophylline clearance with concurrent herb medication
Abstract
- Theophylline undergoes extensive metabo lism(above about 80% of total dose)and is also excreted as aparent drug through kid ney(below about 15% of total dose). The metabolism of theophylline involves hepatic microsomal enzyme and xanthine oxidase. Thus we should be cautions on change of theophylline metabolism with concurrent hepatic enzyme inducers or inhibitors. The first case of 63 years old patient with brmchial aethma showed 39% reduction of theophylline clearance with concurrent herb medication while the second case of 57 years old does 60% increment. These two case reports suggeet that herbal meehication may affect theophylline metabolism.
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