J Korean Neurosurg Soc.  1997 Jan;26(1):48-53.

Comparative Study of the Proliferating Cell Nuclear Antigen and Clinicopathological Features in Intracranial Meningiomas

• Kim CH
• Ha YI

Abstract

The PC10, a monoclonal antibody(mAb) to proliferating cell nuclear antigen(PCNA), is known to show immunoreactivity in paraffin embedded tissue. The authors present the relation between PCNA expression and clinicopathological features such as patient's age and sex, tumor size and location, histological types, and recurrence in 18 intracranial meningiomas. PCNA scores were obtained by immunostaining of the paraffin embedded surgical specimens using a streptoavidin/peroxidase method with PC10 mAb, which recognized an epitope on the PCNA. Univariate analysis showed that high PC10 scores were associated with old age(>or=50 years old), male, recurrent tumor and meningothelial type. However, these high scores did not reach statistical significance(p>0.05). PC10 scores of basal meningioma tended to be higher than that of hemispheric meningioma(p<0.05). The staining intensity of PCNA was markedly increased in basal meningiomas. It is suggested that the proliferative potential is higher in basal meningiomas than in hemispheric meningiomas, however, the number of patients in this study is too small to draw a statistical conclusion.

Keyword

Meningioma; PCNA; Clinicopathological features

MeSH Terms

Humans
Male
Meningioma*
Paraffin
Proliferating Cell Nuclear Antigen*
Recurrence
Paraffin
Proliferating Cell Nuclear Antigen