Korean Circ J.  1982 Jun;12(1):89-97. 10.4070/kcj.1982.12.1.89.

Effect of Nitroglycerin on Systolic Time Intervals

• Choi CP
• Kwon CW
• Kim JG
• Jun JE
• Park WH
• Park HM

• KMID: 2040201
• DOI: http://doi.org/10.4070/kcj.1982.12.1.89

Abstract

To study the effect and a part of its mechanism of nitroglycerin(NTG) on systolic time intervals(STI), the latter was measured along with heart rate and blood pressure in 125 healthy young adults before and after sublingual administration of 0.6mg of NTG. In addition, serial measurements of these parameters were made in 20 cases out of 125 at three minute intervals for 12 minutes. Following NTG administration, there occurred a significant fall in systolic blood pressure, and rise in heart rate and diastolic blood pressure. Changes in STI induced by NTG were a significant abbreviation of the left ventricular ejection time(LVET), and a prolongation of the pre-ejection period(PEP) caused by the lengthening of both isovolumic contraction time(ICT) and transformation period. This resulted in increase and decrease in the ratios of PEP/LVET and LVET/ICT, respectively. The changes in all of these parameters were more pronounced in three to nine minutes after NTG administration, but they persisted until 12 minutes after the medication. It is considered that alteration of STI after NTG administration is related, at least partially, to the reduction of preload caused by venodilation and resultant reflex sympathetic activity accompanying increased afterload.

MeSH Terms

Administration, Sublingual
Blood Pressure
Heart Rate
Humans
Nitroglycerin*
Reflex
Systole*
Young Adult
Nitroglycerin