Korean Circ J.  1982 Dec;12(2):1-19. 10.4070/kcj.1982.12.2.1.

Studies on Platelet Aggregate Ratio and Plasma Free Fatty Acid Level in Myocardial Infarction and Cerebral Thrombosis

• Koh YB
• Lee YW

• KMID: 2040169
• DOI: http://doi.org/10.4070/kcj.1982.12.2.1

Abstract

Platelet aggregate ratio and fasting plasma free fatty acid level were measured to evaluate their roles and correlation as the contributing factors leading to clinical events of atherosclerotic vascular disease. Sixty six normal subjects and, sixty seven paients with myocardial infarction and cerebral thrombosis were involved for the study. The platelet aggregate ratio was determined by a modification of a method described by Wu and Hoak, and the plasma free fatty acid level was measured by Acyl CoA synthetase-Acyl CoA oxidase method with spectrophotometry. The following results were obtained. 1. The mean platelet aggregate ratio for the 31 normal subjects was 0.84+/-0.07. The reatios did not differ significantly between normal female and male or between younger and older normal subjects. The mean plasma free fatty acid level for the 35 normal subjects was 662.4+/-347.9micromol/L and the value was significantly higher in normal female than male, but there was no significant difference between normal younger and older subjects. 2. The mean platelet aggregate ratio in the acute phase of myocardial infarction was lowest significantly within 24 hours of the onset and increased gradually to the steady level on the third day after the onset. This steady level was significantly lower than that of normal subjects and continued during the course of old myocardial infarction. 3. The mean plasma free fatty acid level in the acute phase of myocardial infarction was significantly higher within 24 hours of the onset and was gradually decreasing to the lowest level on the seventh day after the onset. There after the level was increasing gradually to the steady level which was lower than that of normal subjects even in old myocardial infarction. 4. The mean platelet aggregate ratio and plasma free fatty acid level did not differ significantly between the group of patients with and without congestive heart failure in the acute phase of myocardial infarction. But the mean platelet aggregate ratio in the group of patients with arrhythmia showed significantly lower value than the group of patients without arrhythmia. The mean plasma free fatty acid level in the group of patients with arrhythmia showed higher value than the group of patients without arrhythmia, but there was no significant difference. 5. There was no significant correlation between plasma free fatty acid levels and platelet aggregate ratios in the acute phase of myocardial infarction. 6. There was no significant correlation between the maximal serum GOT levels and the initial plasma free fatty acid levels in the acute phase of myocardial infarction. 7. The changes of platelet aggregate ratio in cerebral thrombosis showed the same pattern with those in myocardial infarction. But the changes of plasma free fatty acid in cerebral thrombosis showed a different pattern with those in myocardial infarction. 8. The platelet aggregate ratio might be a good index for evaluating the effect of platelet aggregation inhibitor.

MeSH Terms

Acyl Coenzyme A
Arrhythmias, Cardiac
Blood Platelets*
Fasting
Female
Heart Failure
Humans
Intracranial Thrombosis*
Male
Myocardial Infarction*
Oxidoreductases
Plasma*
Platelet Aggregation
Spectrophotometry
Vascular Diseases
Acyl Coenzyme A
Oxidoreductases