The Effect of Intravenous Solu-cortef on Vecuronium Induced Muscle Twitch Height Rabbit

Chon, Se Ung

Abstract

It is a widespread clinical practice to administer large doses of corticosteroids to patients in cases of shock and or neurosurgery; corticosteroids given intravenously have been proposed and used. Corticosteroids, when administered in this way during surgery have been implicated in intera- ctions with neuromuscular blocking agents. Therefore, the effects of Solu-cortef in the neuromuscular blockade produced by vecuronium were studied in vivo on the indirectly stimulated tibialis anterior muscles of the rabbits aneth- etized with urethane and pentothal sodium. Control group of rabbits was given intravenous boius of 0.1 mg/kg vecuronium to produce twitch depression and recovery as recorded by biophysiograph and measured at anterior tibialis muscle twitch in response to common peroneal nerve by double burst stimulation (DBS). First study group (S-l group) of rabbits was given intravenous bolus of 16 mg/kg Solu- cortef thirty minutes before, and then 0.1 mg/kg vecuronium intravenous bolus was given. Twitch depression and recovery was measured as control group. Seeond study group (S-2 group) of rabbits was given intravenous bolus of 0.1 mg/kg vecuronium during recovery phase, intravenous bolus of 16 mg/kg Solu-cortef was given at DBS ratio 0.5. Statistical analysis was confirmed by oneway ANOVA test,followed by Student- Newman-Keuls test. The results were as follows', 1) In control group,'recovery times to DRS ratio at 0.5 and 0.8 were 1,089.2+42.94 and 1,272.0 +'54.87 sec. 2) In first study group',axovery times to DBS ratio at 0.5 and 0.8 were 1,208.8>61.95 and 1,417.4+65.02 sec. It shows some what prolonged recovery time than control but statistically not significant. 3. In second study group;recovery times to DBS ratio at 0.5 was 1,218.4+/-61.16 sec. DBS ratio was deereased to 0.22 when intravenous bolus of Solu-cortef was given,thereafter DBS ratio was gradually increased Recovery times to DBS ratio at 0.5 and 0,8 were 1,444.0 and 1,633.8+/-65.02 sec. More prolonged recovery times were observed. It was statistically significant to compare with control and first study group (P<0,05). By the above results ; acute intravenous bolus Solu-cortef may affeet the vecuronium induced neuromuscular block in rabbits.