Korean J Dermatol.  2013 Jan;51(1):49-52.

Leukocytoclastic Vasulitis Induced by Methoxy Polyethylene Glycol-Epoetin Beta

• Lee SY
• Go JW
• Kim SH
• Son HO
• Cho HK

Abstract

Methoxy polyethylene glycol-epoetin beta (Mircera(R), Roche), a third-generation erythropoiesis-stimulating agent (ESA) is known as a continuous erythropoietin receptor activator (CERA). In patients with anemia associated with chronic kidney disease (CKD), it is administered intravenously or subcutaneously. Treatment-related adverse events induced by methoxy polyethylene glycol-epoetin beta occurred in 6%. Hypertension, diarrhea and nasopharyngitis were the most commonly reported adverse events. Cutaneous adverse reactions are rarely experienced with methoxy polyethylene glycol-epoetin beta including maculopapular eruption, facial erythema, and tinea pedis. To the best of our knowledge, no cases of leukocytoclastic vasculitis associated with methoxy polyethylene glycol-epoetin beta have ever been published in medical literature. Herein, we report on a case of leukocytoclastic vasulitis induced by methoxy polyethylene glycol-epoetin beta in a patient with anemia associated with chronic kidney disease.

Keyword

Leukocytoclastic vasculitis; Methoxy polyethylene glycol-epoetin beta; Mircera(R)

MeSH Terms

Anemia
Diarrhea
Erythema
Erythropoietin
Humans
Hypertension
Nasopharyngitis
Polyethylene
Polyethylene Glycols
Receptors, Erythropoietin
Renal Insufficiency, Chronic
Tinea Pedis
Vasculitis
Vasculitis, Leukocytoclastic, Cutaneous
Erythropoietin
Polyethylene
Polyethylene Glycols
Receptors, Erythropoietin
Vasculitis, Leukocytoclastic, Cutaneous