Korean J Gastroenterol.  2002 Apr;39(4):269-274.

Usefulness of Colon Transit Scintigraphy in Colonic Inertia Using 67Ga-labelled Methacrylate Coated Capsule

• Kim TH
• Choi CS
• Choi SC
• Kim SW
• Choi JH
• Yeom JJ
• Yoon KH
• Kim CG
• Nah YH

Abstract

BACKGROUND/AIMS: This study was perfomed to evaluate usefulness of scintigraphic measurement of orocecal transit and regional colonic transit using 67Ga-labelled pellets with methacrylate coated capsule in patients with colonic inertia and healthy volunteers.
METHODS
Ten patients with colonic inertia and 10 healthy volunteers underwent scintigraphic measurement of the orocecal and regional colonic transit using 67Ga-labelled pellets with methacrylate coated capsule. Images were obtained using a gamma camera at 2, 4, 8, 24 and 48 hours after initial counting of the radioactivity in the cecum.
RESULTS
Ten patient with colonic inertia showed significant retention of solid residue in the ascending and transverse colon over a 48-hour-period. The median value of geometric center (mean+/-SE) for the healthy subjects at 2, 4, 8, 24, and 48 hours were 1.24+/-0.18, 1.48+/-0.28, 1.72+/-0.35, 3.03+/-0.96, and 5.0+/-0.0, respectively. On the contrary, the values of ten patients with colonic inertia were 1.0+/-0.0, 1.0+/-0.0, 1.02+/-0.06, 1.70+/-0.36, and 2.33+/-0.31 (p<0.001). Orocecal transit time was significantly longer in patients with colonic inertia than healthy volunteers (8.67+/-2.14 vs. 6.75+/-1.48 p<0.05).
CONCLUSIONS
Scintigraphy using 67Gallium-labelled pellets with methacrylate coated capsule seems to be a useful tool to measure the orocecal transit and segmental colon transit in patients with colonic inertia.

Keyword

Colonic inertia; 67Gallium; Scintigraphy

MeSH Terms

Cecum
Colon*
Colon, Transverse
Constipation*
Gamma Cameras
Healthy Volunteers
Humans
Radioactivity
Radionuclide Imaging*