Korean J Lab Med.
2005 Aug;25(4):262-266.
A Case of Hemorrhagic Fever with Renal Syndrome by Seoul Virus Confirmed by Reverse Transcription-Polymerase Chain Reaction-Restriction Fragment Length Polymorphism
- Affiliations
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- 1Department of Laboratory Medicine, Boramae Hospital1, Korea.
- 2Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea. euichong@snu.ac.kr
- 3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Members of the genus Hantavirus are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS), the diagnosis of which is somewhat difficult because several diseases share similar early clinical presentations such as fever and petechia. In Korea, Hantaan virus and Seoul virus are the causative organisms of HFRS, and the infection caused by Seoul virus is milder than that caused by Hantaan virus. We report a 44-year-old woman, who visited our hospital due to general weakness, fever, myalgia, facial edema and diarrhea. She was diagnosed with HFRS caused by Seoul virus. The antibody against Hantaan virus was positive by an indirect immunofluorescent test and the discrimination between Hantaan and Seoul viruses was done by RT-PCR-RFLP (reverse transcriptionpolymerase chain reaction-restriction fragment length polymorphism) against viral S segment.
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