Korean J Lab Med.  2005 Apr;25(2):129-132.

Thrombotic Thrombocytopenic Purpura after Autologous Peripheral Blood Stem Cell Transplantation

• Kim MH

Abstract

Thrombotic thombocytopenic purpura (TTP) is a serious complication following stem cell trans-plantation (SCT). Although therapeutic plasma exchange offers an encouraging treatment modality in classic TTP, this does not appear to be effective in its management of TTP following SCT. This patient with malignant lymphoma developed TTP two months after autologous peripheral blood SCT and was effectively treated with plasma exchange and steroid therapy. Plasma exchange with fresh frozen plasma and albumin was performed 14 times in 40 days. Even though TTP may emerge as a complication of autologous peripheral blood SCT, this report suggests that the risk of developing TTP after autologous peripheral blood SCT may be low and a multiple course of plasma exchange may be an effective treatment in this patient.

Keyword

Thrombotic thrombocytopenic purpura; Autologous peripheral blood stem cell transplantation; Plasma exchange

MeSH Terms

Humans
Lymphoma
Peripheral Blood Stem Cell Transplantation*
Plasma
Plasma Exchange
Purpura
Purpura, Thrombotic Thrombocytopenic*
Stem Cells