Korean J Obstet Gynecol.  2011 Feb;54(2):115-118. 10.5468/KJOG.2011.54.2.115.

A case of Peutz-Jeghers syndrome with endometrial adenomyomatous polyp

• Lee YH
• Hong DG
• Bae JH
• Park NY
• Chong GO
• Lee YS

• KMID: 2037502
• DOI: http://doi.org/10.5468/KJOG.2011.54.2.115

Abstract

Peutz-Jeghers syndrome, which has autosomal dominant inheritance, shows pigmentation in lip and skin. It also has features of harmatomatous polyp over the gastrointestinal tract, while sometimes developing tumor in genital tract. Known tumors in female genital tract include cervical adenocarcinoma, sex cord tumor, etc. Adenomyomatous polyp in uterus is also one of the rare diseases, which seldom develop in the absence of hormone treatment such as Tamoxifen. Currently, there is one case of Peutz-Jeghers syndrome patient with endometrial adenomyomatous polyp. Authors found mole-like lesions on the transvaginal ultrasonogram in a typical Peutz-Jeghers syndrome patient without pregnancy history and previous chemotherapy. After confirming its diagnosis of adenomyomatous polyp on resectoscopic biopsy, we report our fihndings along with brief literature review.

Keyword

Peutz-Jeghers syndrome; Adenomyomatous polyp; Resectoscopy

MeSH Terms

Adenocarcinoma
Biopsy
Female
Gastrointestinal Tract
Humans
Lip
Peutz-Jeghers Syndrome
Pigmentation
Polyps
Rare Diseases
Reproductive History
Skin
Tamoxifen
Uterus
Wills
Tamoxifen

Figure

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  Fig. 1 Adnomyotous polyps characterized histologically by the intertwining of smooth muscle, endometrial glands and endometrial stroma. (A) The polyp contains many cystically dilated glands and abundant smooth muscle fibers (H&E, ×40). (B) Insert, The white arrows represent smooth muscle fibers in stroma (H&E, ×40). (C) The brown color in stroma reveals positive reactivity upon smooth muscle actin (immunohistochemistry for smooth muscle actin, ×40).

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  Fig. 2 The polyp resected at the duodenum and resected polyps showed hyperplastic and dilated glands which were compatible with hamartomatous polyp in same patient (H&E, ×40).

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