Korean J Pathol.  1998 Apr;32(4):283-289.

A Study of Correlation between Stage and Angiogenesis f Uterine Cervical Squamous Cell Carcinoma

• Lee ES
• Kim IS

Abstract

A variety of malignant neoplasms have been shown to induce neovascularization, and in some cases the degree of vascularization appears to correlate with an aggressive behavior and risk of metastasis. We compared the degree of vascularization in 11 benign and 33 cancerous lesions of the cervix. The microvessels were identified by immunohistochemistry using antibody to Factor VIII-related antigen in 44 hystrectomy specimens. Three highly vascularized microscopic fields were selected and counted the number of microvessels in 400 magnification. The proportion of the endothelial cell area was also quantified by using the CAS 200 image analysis system. All 33 cases of carcinomas demonstrated a significantly higher microvessel count and an endothelial cell area than those of the benign lesions (p<0.01). There were no significant difference in microvessel count and endothelial cell area among carcinoma in situ, microinvasive carcinoma and invasive carcinoma (p>0.05). Microvessel count and an endothelial cell area in invasive cancers were not correlated with tumor size, depth of invasion, or histologic type (p>0.05).This study showed cervical cancer induces neovascularization in an early stage but it is difficult to predict prognosis and metastasis with microvessel count and an endothelial cell area.

Keyword

Angiogenesis; Neovascularization; Uterine cervix; Squamous cell carcinoma; Morphometric quantitation

MeSH Terms

Carcinoma in Situ
Carcinoma, Squamous Cell*
Cervix Uteri
Endothelial Cells
Female
Immunohistochemistry
Microvessels
Neoplasm Metastasis
Prognosis
Uterine Cervical Neoplasms
von Willebrand Factor
von Willebrand Factor