The factors affecting treatment of radiation hemorrhagic cystitis

Choi, Jong Geun; Rhew, Hyun Yul

Abstract

Hemorrhagic cystitis remains a significant complication and morbidity after local radiation therapy to the pelvic region despite close attention to various preventive measures and it was poor response to multi-modality therapies. We have analyzed some factors affecting treatment of radiation hemorrhagic cystitis. 2,238 patients were admitted to the Department of Urology. Kosin Medical College, Pusan, Korea between May. 1985 and February, 1990. Among them 28(1.3%) cases were diagnosed in radiation hemorrhagic cystitis. The most common cause for radiation therapy was uterine cervical cancer(92.9%). The major symptoms were gross hematuria, frequency, nocturia, dysuria and nausea. Under the cystoscopy, the bladder mucosa was seen hyperemia, telangiectasia, mucosal edema and focal necrosis. The combined disease was 4 cases, radiation colitis in 2 cases, radiation proctitis in 1 case and neurogenic bladder in 1 case. There was statistical significant in recurrence rate between receive more than 4,600 rad and less than 4.600 rad (p<0.05). And there was statistically significant in consumption time for treatment between combined with urinary tract infection (41.7 %) and not combined with it (31.3 %)(p<0.05). The patients were controlled with cold saline irrigation, intravesical formalin instillation and hyperbaric oxygen therapy.