Yonsei Med J.
1992 Dec;33(4):368-373. 10.3349/ymj.1992.33.4.368.
Thyrotropin-secreting pituitary microadenoma
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2036546
- DOI: http://doi.org/10.3349/ymj.1992.33.4.368
Abstract
- We present a 45-yr-old male with clinical signs and symptoms of mild hyperthyroidism, high serum levels of T3, T4, and FT4 as well as serum TSH concentration. The elevated alpha-subunit level and alpha-subunit/TSH molar ratio were also observed. These findings indicated the presence of hyperthyroidism due to inappropriate secretion of TSH, whose neoplastic origin was documented by nuclear magnetic resonance scan showing a 0. 6 cm pituitary adenoma. Selective pituitary adenomectomy was completely successful; alpha-subunit, TSH, T3, T 4, and FT4 normalized, and euthyroidism was restored. Light microscopic immunohistochemistry showed that the adenoma was composed of TSH-secreting cells
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