Korean J Anesthesiol.  2000 Oct;39(4):563-567. 10.4097/kjae.2000.39.4.563.

The Effects of Mivacurium on Isolated Rat Tracheal Muscle

• Ko YK
• Lee JU
• Shin YS
• Son SC
• Lee WH
• Choi SJ

• KMID: 2031618
• DOI: http://doi.org/10.4097/kjae.2000.39.4.563

Abstract

BACKGROUND: Neuromuscular blocking drugs are designed to specifically block nicotinic cholinergic receptors at the neuromuscular junction, but many bind to muscarinic cholinergic receptors on ganglia, nerve endings, and smooth muscles, thereby altering parasymphathetically mediated airway caliber and heart rate. METHODS: We studied the effects of mivacurium on the tension of tracheal smooth muscle by using an isolated rat tracheal preparation. We studied the cumulative effect of acetylcholine after pretreating the tracheal smooth muscle with mivacurium at different concentrations, as well as the effect of L-NAME and propranolol on the tension of tracheal smooth muscle after pretreating with mivacurium. RESULTS: Mivacurium shifted the acetylcholine dose-response curve to the right. L-NAME and propranolol had no effect on the tension of tracheal smooth muscle after pretreating with mivacurium. CONCLUSIONS: We have found that mivacurium relaxes isolated rat tracheal smooth muscle and this effect has no relationship to beta-receptors or nitric oxide.

Keyword

Muscle relaxant: mivacurium; Smooth muscle: rat trachea

MeSH Terms

Acetylcholine
Animals
Ganglia
Heart Rate
Muscle, Smooth
Nerve Endings
Neuromuscular Blockade
Neuromuscular Junction
NG-Nitroarginine Methyl Ester
Nitric Oxide
Propranolol
Rats*
Receptors, Cholinergic
Acetylcholine
NG-Nitroarginine Methyl Ester
Nitric Oxide
Propranolol
Receptors, Cholinergic