Korean J Anesthesiol.
2000 Aug;39(2):196-201. 10.4097/kjae.2000.39.2.196.
The Effect of Clonidine Added to Bupivacaine on Intercostal Nerve Block for Postoperative Pain Control
- Affiliations
-
- 1Department of Anesthesiology, Wallace Memorial Baptist Hospital, Pusan, Korea.
- KMID: 2031561
- DOI: http://doi.org/10.4097/kjae.2000.39.2.196
Abstract
-
BACKGROUND: The addition of clonidine to local anesthetics for regional block has been shown to increase the duration of anesthesia and analgesia. This study was designed to determine whether the addition of clonidine to bupivacaine would produce an extension of the analgesic effect after intercostal nerve block (ICNB).
METHODS
After informed consent, 30 ASA 1 or 2 patients undergoing appendectomy under general anesthesia were randomly divided into two groups. Before induction of anesthesia, ICNB using a posterior approach was performed with 15 ml of 0.25% bupivacaine plus epinephrine 1:200,000 with (Group BEC; n = 15) or without (Group BE; n = 15) clonidine 75 microgram. Analgesia was assessed by cold testing at 1/min intervals until cold sensation decreased. The duration of analgesia (time between injection and onset of pain) was recorded. We also recorded the visual analogue scale (VAS) of pain, the number of supplemental analgesics, heart rate and blood pressure, and side effects over 24 hours postoperatively.
RESULTS
The onset time, duration of analgesia, number of analgesics, and heart rate and blood pressure were comparable in both groups. VAS scores were significantly lower in Group BEC than in Group BE at 12, 16, and 20 hours postoperatively.
CONCLUSIONS
The addition of clonidine to bupivacaine with epinephrine may be a useful adjunct and can prolong the duration of analgesia after ICNB without significant side effects.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effect of the Thoracic Epidural Analgesia on Postoperative Pain and Pulmonary Function Recovery after Thoracoscopic Surgery
- A Case of Sudden Hypotension Following Intraoperative Intercostal Nerve Block
- Comparison of Changes in Plasma Potassium Levels Induced by Brachial Plexus Block with Admixture of Clonidine or Epinephrine to 0.5 % Bupivacaine
- The Effect of Preoperative Intercostal Nerve Block on Postoperative Pain after Appendectomy
- The Effect of Clonidine Administered with Bupivacaine in Brachial Plexus Block
