Korean J Anesthesiol.  1999 Dec;37(6):1054-1059. 10.4097/kjae.1999.37.6.1054.

Prevention of Nausea and Vomiting during Spinal or Epidural Anesthesia for Cesarean Section - The Efficacy of Metoclopramide and Droperidol -

• Choi DH
• Kim SC
• Sim WS

• KMID: 2031447
• DOI: http://doi.org/10.4097/kjae.1999.37.6.1054

Abstract

BACKGROUND: Regional anesthesia for cesarean section is associated with a high incidence of nausea and/or vomiting (N&V) during the operation. Metoclopramide and droperidol have been known to be effective in the prevention of N&V. However, they have been reported to induce some adverse effects such as sedation. We evaluated the efficacy of metoclopramide and droperidol in the prevention of N&V in spinal and epidural anesthesia for cesarean section.
METHODS
A prospective randomized double-blind study was performed on 180 parturients scheduled for elective cesarean section. They were allocated into spinal or epidural (n = 90, each) anesthesia groups and each group into either a placebo, metoclopramide, or droperidol drug group (n = 30, each). After delivery, 2 ml saline, 10 mg metoclopramide, or 0.625 mg droperidol was given to the parturients, respectively. Incidences of N&V and sedation during the operation were checked, and the other adverse effects of the anesthesias such as hypotension and visceral pain were compared among the groups. The height of sensory blockade was also checked.
RESULTS
Epidural anesthesia was more related with N&V than spinal (P = 0.030). Among the groups there was a significant difference in the incidence of N&V (P = 0.002). There were fewer parturients with N&V in the droperidol group than in the placebo group during epidural anesthesia (P = 0.021). During both spinal and epidural anesthesia more parturients in the droperidol group had sedation than placebo or metoclopramide groups (P = 0.0001) and more in the metoclopramide group than in the pacebo group (P = 0.01). No differences were found in incidences of hypotension and in the height of sensory block among the groups. There were more parturients with visceral pain during epidural anesthesia (P = 0.031).
CONCLUSIONS
Epidural anesthesia provoked N&V more frequently than spinal anesthesia for cesarean section. Only droperidol was effective in the prevention of N&V during epidural anesthesia, but had a more sedative effect than metoclopramide during either spinal or epidural anesthesia.

Keyword

Anesthetic technique, spinal, epidural; Pregnancy, cesarean section; Vomiting, antiemetics, droperodol, metoclopramide, nausea

MeSH Terms

Anesthesia
Anesthesia, Conduction
Anesthesia, Epidural*
Anesthesia, Spinal
Cesarean Section*
Double-Blind Method
Droperidol*
Female
Hypnotics and Sedatives
Hypotension
Incidence
Metoclopramide*
Nausea*
Pregnancy
Prospective Studies
Visceral Pain
Vomiting*
Droperidol
Hypnotics and Sedatives
Metoclopramide