Korean Diabetes J.  2008 Aug;32(4):338-345. 10.4093/kdj.2008.32.4.338.

Relationship Between Serum Bilirubin Levels and Coronary Atherosclerosis in Patients with Type 2 Diabetes

• Moon JS
• Chang WJ
• Lee CH
• Lee JE
• Chun KA
• Yoon JS
• Cho IH
• Lee HW
• Won KC

• KMID: 2029820
• DOI: http://doi.org/10.4093/kdj.2008.32.4.338

Abstract

BACKGROUND: Lipid oxidation and formation of oxygen radicals have been identified to be the important factors of atherogenesis. Because bilirubin, a potent physiological antioxidant inhibits lipid oxidation, it is suggested that low serum concentrations of bilirubin is associated with atherosclerosis. The aim of this study was to evaluate the relationship between bilirubin levels and coronary atherosclerosis.
METHODS
The coronary calcium score (CCS) of 172 subjects (male 63, mean age 60.5 +/- 1.0) with type 2 diabetes were evaluated in Yeungnam University Hospital between January 2005 and February 2007. The subjects were divided into two groups with CCS 10 as the cut off.
RESULTS
Higher CCS was significantly associated with lower bilirubin (P < 0.05), but after adjusted with age, no longer correlation were seen (P = 0.121). To determine the relationship between subclinical coronary atherosclerosis and bilirubin, the subjects with previous history of cardiovascular disease were excluded. In 138 subjects (male 54, mean age 58.4 +/- 1.1), higher CCS was significantly associated with lower levels of bilirubin. After adjusted with age, duration of diabetes, and history of hypertension, CCS was also inversely related with bilirubin (P < 0.05).
CONCLUSION
These results suggest that lower levels of bilirubin might be considered as a risk factor of coronary artery disease, especially in type 2 diabetics without cardiovascular disease.

Keyword

Bilirubin; Cardiovascular disease; Coronary calcium score; Type 2 diabetes

MeSH Terms

Atherosclerosis
Bilirubin
Calcium
Cardiovascular Diseases
Coronary Artery Disease
Humans
Hypertension
Reactive Oxygen Species
Risk Factors
Bilirubin
Calcium
Reactive Oxygen Species

Figure

• 

  Fig. 1 Serum total bilirubin level in patients of type 2 diabetes without coronary artery disease. Higher CCS was significantly associated with lower levels of bilirubin. CCS, coronary calcium score. *P < 0.05.

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