Korean Circ J.
2001 Oct;31(10):973-981. 10.4070/kcj.2001.31.10.973.
Association of Endothelial NO Synthase Gene Glu298Asp Polymorphism with Acute Myocardial Infarction
- Affiliations
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- 1Department of Family Medicine, College of Medicine, Catholic University, Korea.
- 2Department of Preventive Medicine, College of Medicine, Catholic University, Korea.
- 3Department of Internal Medicine, College of Medicine, Catholic University, Korea.
- KMID: 2029582
- DOI: http://doi.org/10.4070/kcj.2001.31.10.973
Abstract
- BACKGROUND
AND OBJECT: Several studies suggest that endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism is associated with coronary heart disease. We evaluated the relation between eNOS Glu298Asp polymorphism and the risk factors for myocardial infarction. MATERIALS AND METHOD: We selected 102 acute myocardial infarction (AMI) male patients younger than 65 years old and 112 healthy men as age matched controls. The eNOS genotypes were determined from blood lymphocyte DNA samples by using PCR-RFLP method.
RESULTS
There was no difference in frequency of eNOs Glu298Asp polymorphism between the AMI and control groups. eNOS Glu298Asp polymorphism was not an independent risk factor for AMI. However smoking, smoking amount, hypertension, hypercholesterolemia, high fasting sugar and low HDL-cholesterol were independent risk factors (p<0.01). Among the subjects having the eNOS GG genotype, the smokers had 3 times higher risk of AMI compared with nonsmokers (p=0.0413). Among the subjects having the eNOS TT or GT genotype, the smokers had 15 times higher risk of AMI compared with nonsmokers (p=0.0271). Among the subjects having the eNOS GG genotype, the high risk group had 21.9 times higher risk of AMI compared with the low risk group (p=0.0001). Among the subjects having eNOS TT or GT genotype, the high risk group had 31.9 times higher risk of AMI compared with the low risk group (p=0.0089).
CONCLUSION
eNOS TT or GT genotype demonstrated a synergistic effect with smoking and high risk group on the risk of AMI.
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