Korean J Biol Psychiatry.
2008 Aug;15(3):152-174.
Schizophrenia and Immunological Abnormalities
- Affiliations
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- 1Department of Neuropsychiatry, Seoul National University, Boramae Medical Center, Seoul, Korea. hyjung@snu.ac.kr
- 2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
- 3Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- There have been vast amount studies regarding immunologic dysregulation in schizophrenia. The mechanism of immune pathogenesis in schizophrenia still is unclear, even though various immune dysfunction have been reported. We endeavored to report on two major hypothesis on immunologic dysregulation in schizophrenia, the infection hypothesis and autoimmune hypothesis. We went on to focus on the autoimmune hypothesis, which has received the most attention over the years. We explored the accumulated data and the rational behind the autoimmune hypothesis and the implications of the autoimmune hypothesis for future research in the pathogenesis of schizophrenia
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