J Korean Rheum Assoc.
1996 Jan;3(1):50-56.
Soluble Fas Expression in Systemic Lupus Erythematosus
- Affiliations
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- 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To investigate soluble Fas (sFas) protein in the sera of patients with systemic lupus erythematosus (SLE).
METHODS
sfas protein was measured by sandwich ELISA METHOD: in the sera of 30 patients with SLE (mean age : 27.4+/-8.46, F:M=29:1) and 11 patients with fibromyalgia (mean age 35.8+/-11.5, F:M-11:0) as a control group.
RESULTS
sfas was elevated in 6 (20%) patients of SLE and I (9%) of patients with fibromyalgia (p=0.41). sfas level was correlated with a shorter duration, lower dosage of systemic steroid and higher disease activity in patients with elevated sfas levlel compared to patients with normal serum levels of sfas. All patients with elevated sfas had been diagnosed with SLE for less than 1 month. Fifty % (6 out of 12)patients with SLE for less than I month showed elevated sfas in serum. There was no difference of in the age between patients with elevated and normal levels of sfas.
CONCLUSION
These data indicate that elevated sera levels of sfas was associated with the early active phase of disease in some patients with SLE and may play a role in defective apoptosis.
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