Indocyanine Green Angiographic Findings in Harada Disease

Kim, In Taek; Choi, Hee Kyu; Kim, Hong Kyun

Abstract

ICG angiography, an excellent method for the study of choroidal disorders, was used to evaluate the intraocular vascular abnormalities associated with Harada disease. 25-year-old male with Harada disease was examined by using fluorescein angiography and ICG angiography during the whole course of the disease. In the acute stage of the disease, FAG showed dye leakage and pooling into the subretinal space in the posterior pole. The dye leakage and pooling were improved or disappeared during follow up period. In ICG angiography, filling delay of choroidal circulation and numerous hypofluorescent spots were the most remarkable findings in the acute stage of the disease. In the early to late phase choroidal vessels were indistinct. The filling delay and indistinct choroidal vessels in the acute stage were gradually improved or more clearly visualized during the whole course of the disease. However, multiple hypofluorescent spots were still present till the recovery stage of the disease. Also, ICG angiography showed several dye leakages as hyperfluorescent spots and pooling as hypofluorescent or hyperfluorescent area. The choroidal tissue staining appeared during the recovery stage of the disease. ICG angiography clearly revealed the disturbance of choroidal circulation in Harada disease, and filling delay of the choroidal circulation and indistinct choroidal vessels. ICG angiography helps to demonstrate the pathologic findings of Harada disease clinically.