J Korean Neurosurg Soc.  2004 Feb;35(2):147-152.

Effect of Intraarterially Administered Abciximab(Glycoprotein IIb-IIIa Inhibitor) in the Acute Cerebral Vascular Occlusion

• Kim YM
• Choe WJ
• Kwon OK
• Lee CH
• Park HI
• Koh YC

Abstract

OBJECTIVE
The authors report the safe recanalization after intraarterial injection of abciximab(glycoprotein IIb-IIIa inhibitor) in the acute cerebral vascular occlusion from the thromboembolism. METHODS: Eight patients with acute occlusion of cerebral arteries were treated by using an intraarterial infusion of urokinase and abciximab(Reopro(R)). Six patients had acute thromboembolic complication of endovascular therapy and two patients had acute basilar artery occlusion. Authors used mean 428, 000 units of the urokinase, and mean 6.2mg of the abciximab. In six cases, intraarterial urokinase and abciximab were infused shortly after the event of thrombosis duration endovascular procedure. RESULTS: In all cases, successful recanalization of thrombotic artery was achieved by using intraarterial abciximab and urokinase without bleeding complication. Seven patients recovered without neurologic deficit and one patient remained in locked-in neurological state. CONCLUSION: The authors believe that the intraarterial infusion of abxicimab even in small dose is effective and safe recanalization method in acute thrombotic occlusion of cerebral arteries, but further evaluation and study are needed.

Keyword

Abciximab; Intraarterial recanalization; Acute cerebral vascular occlusion

MeSH Terms

Arteries
Basilar Artery
Cerebral Arteries
Endovascular Procedures
Hemorrhage
Humans
Infusions, Intra-Arterial
Injections, Intra-Arterial
Neurologic Manifestations
Thromboembolism
Thrombosis
Urokinase-Type Plasminogen Activator
Urokinase-Type Plasminogen Activator