J Korean Neurosurg Soc.  2010 Dec;48(6):524-527. 10.3340/jkns.2010.48.6.524.

Transient Global Aphasia with Hemiparesis Following Cerebral Angiography : Relationship to Blood Brain Barrier Disruption

• Kim DH
• Choi CH
• Lee JH
• Lee JI

• KMID: 2018399
• DOI: http://doi.org/10.3340/jkns.2010.48.6.524

Abstract

Temporary disruption of the blood-brain barrier (BBB) after cerebral angiography is presumably caused by nonionic radiographic contrast medium (CM). We hereby report a case of 58-year-old woman who developed decreased mentality, global aphasia and aggravated right hemiparesis after cerebral angiography. Brain CT examination demonstrated gyriform enhancement throughout the left cerebral cortex and thalamus. MR diffusion did not reveal acute infarction. MR angiography did not show any stenosis, spasm or occlusion at the major cerebral vessels. Follow-up CT scan after 1 day did not show any gyriform enhancement. Worsened neurologic signs and symptoms were improved completely after 7 days. In the present study, disruption of the BBB with contrast medium after angiography seems to be the causative factor of transient neurologic deterioration.

Keyword

Blood brain barrier (BBB) disruption; Contrast medium; Transient global aphasia; Transient hemiparesis; Cerebral angiography

MeSH Terms

Angiography
Aphasia
Blood-Brain Barrier
Brain
Cerebral Angiography
Cerebral Cortex
Constriction, Pathologic
Diffusion
Female
Follow-Up Studies
Humans
Infarction
Middle Aged
Neurologic Manifestations
Paresis
Spasm
Thalamus