J Korean Geriatr Psychiatry.  2002 Jun;6(1):49-56.

Apolipoprotein epsilon4 and Cognitive Function, Daily Living Ability and Behavioral Symptoms of Dementia

• Kim YD
• Lee CH
• Eum KC
• Kim DH
• Yoon KS

Abstract

OBJECTIVES
We investigated the relationship between apolipoprotein epsilon4 and clinical features of dementia.
METHODS
Samples were obtained from 33 dementia patients in Korea, Buyeo Geriatric Hospital and apolipoprotein E polymorphisms were analysed using polymerase chain reaction and restriction fragment length polymorphism. The multidimensional evaluating methods (MMSE-K, B-ADL, BEHAVE-AD, GDS, GMHR) for dementia were performed to analyze relationship with Apolipoprotein E genotypes.
RESULTS
The distributions of the apolipoprotein E genotypes of the dementia patients were presented by epsilon3/epsilon3 (58%), epsilon3/epsilon4 (22%), epsilon2/epsilon3 (15%), and epsilon4/epsilon4 (0%). There is no significant relationship between apolipoprotein epsilon4 and the findings of multidimensional evaluating measures.
CONCLUSION
We could not find the association between apolipoprotein epsilon4 and the scores of the multidimensional evaluating measures of dementia patients. The results suggested that apolipoprotein epsilon4 might not play a main role in cognitive function, daily living ability and behavioral symptoms of dementia.

Keyword

Dementia; Apolipoprotein epsilon4; Multidimensional measures

MeSH Terms

Apolipoproteins*
Behavioral Symptoms*
Dementia*
Genotype
Humans
Korea
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Apolipoproteins