Korean J Dermatol.  2002 May;40(5):513-517.

Therapeutic Effects of Various Antibiotics for the Confluent and Reticulated Papillomatosis

• Kim YJ
• Shin BS
• Kim SH
• Choi KC

Abstract

BACKGROUND: Confluent and reticulated papillomatosis(CRP), the least common of the cutaneous papillomatoses, is manifested by persistent papules that are confluent in center and reticulated at the periphery. Recently, many cases of CRP treated with minocycline have been reported.
METHODS
Thirteen patients with CRP were included in this study. They were treated with various antibiotics, such as erythromycin, tetracycline, doxycycline, and minocycline. The patients have taken antibiotics twice a day for 4 weeks. They were followed-up at 4, 8, 12, and 16 weeks after treatment. We assessed about therapeutic effects, side effects, and recurrence, by phone 1 year after treatment.
RESULTS
Of the total 13 patients, 9 patients had improved by more than 95% in response to various antibiotics therapy for 4 months. One patient had a mild adverse reaction and two patients symptoms recurred after 1 year follow-up.
CONCLUSION
We recommended various antibiotics therapy as the first choice of treatment for CRP because those were safe, economic, and effective.

Keyword

Confluent and reticulated papillomatosis; Antibiotics; Therapy

MeSH Terms

Anti-Bacterial Agents*
Doxycycline
Erythromycin
Follow-Up Studies
Humans
Minocycline
Papilloma*
Recurrence
Tetracycline
Anti-Bacterial Agents
Doxycycline
Erythromycin
Minocycline
Tetracycline