Korean J Obstet Gynecol.  2006 Mar;49(3):682-689.

Three Cases of Sertoli-Leydig Cell Tumor

• Park JW
• Yim KR
• Kim YM
• Kim JY

Abstract

Sertoli-Leydig cell tumors of the ovary are one of the sex cord-stromal tumors. They are very rare, account for less than 0.5% of all ovarian tumor. These tumors are almost unilateral, and occur predominantly at premenopausal state and rarely at postmenopausal and prepubertal. The most specific symptoms are virilization due to hyperandrogenism but it presents only in 40-50% of the patients, and vast majority of the patients complain for non-specific abdominal symptoms and menstrual disorder including vaginal bleeding. Prognosis and treatment modalities for Sertoli-Leydig cell tumors remain controversial as they are rare and only a few studies have been published. Treatment varies with patients age, tumor stage, and differentiation from unilateral salpingo-oophrectomy and total hysterectomy concomitant with pelvic lymph node dissection, and in occasion, adjuvant chemotherapy. Prognosis is generally favorable with 5-year survival rate of 70-90%. Recurrence is rare. We have experienced three cases of Sertoli-Leydig cell tumor, each of them showed different clinical presentation and histologic findings, so we present them with a brief review of literature.

Keyword

Sertoli-Leydig cell tumor

MeSH Terms

Chemotherapy, Adjuvant
Female
Humans
Hyperandrogenism
Hysterectomy
Lymph Node Excision
Ovary
Prognosis
Recurrence
Sertoli-Leydig Cell Tumor*
Sex Cord-Gonadal Stromal Tumors
Survival Rate
Uterine Hemorrhage
Virilism