Korean J Thorac Cardiovasc Surg.  2001 Dec;34(12):956-959.

Lymphoproliferative Disease After Lung Transplantation in Transplanted Lung

Affiliations
  • 1Department of Thoracic & Cardiovascular Surgery, Yongdong Severance Hospital, Yonsei University, Korea.

Abstract

The lymphoproliferative disease after the organ transplantation is more commonly seen with the increase according to the increasing number of the organ transplantations and it occurs more frequently in the cases of heart and lung transplantations that needs more aggressive immunosuppression. It demands urgent evaluation and management because of poor prognosis. We transplanted left lung of a man to the woman who suffered from severe dyspnea due to terminal pulmonary emphysema in discrepancy of ABO blood type. Postoperatively, We used triple regimen immunotherapy(cyclosporin, azathioprine, prednisolone) and followed up in the out patient clinic. During the follow up, we found abnormal mass lesion on the transplanted lung and performed gun biopsy. We confirmed malignant lymphoma on the pathologic examination and two cycled chemotherapy was given after reducing dose of immunosupression. The patient died of sudden onset of pulmonary edema of the transplanted lung.

Keyword

Lung transplantation; Lymphoproliferative disorders; Postoperative complications

MeSH Terms

Azathioprine
Biopsy
Drug Therapy
Dyspnea
Female
Follow-Up Studies
Heart
Humans
Immunosuppression
Lung Transplantation*
Lung*
Lymphoma
Lymphoproliferative Disorders
Organ Transplantation
Postoperative Complications
Prognosis
Pulmonary Edema
Pulmonary Emphysema
Transplants
Azathioprine
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