Study on Urine Alkalizing Agents

Kim, Hyun Woo; Yoon, Jong Byung

Abstract

The authors investigated diurnal change of urinary pH in control group and urine alkalizing group. The control group composed of normal group and hydration group (water 2000 cc/day). The urine alkalizing agent group composed of sodium bicarbonate group (4gm/day, 6mg./day, 8gm/day and 12gm./day) and citrate agent groups (Eisenberg`s solution; 60cc/day and CG-120 or Uralyt-U;4gm./day) in 15 normal healthy adult male. The results were summarized as follows; 1. In normal control group and hydration group, diurnal urinary pH were 5.89+0.47 and 6.00 + 0.44 respectively, There was no significant difference between normal control group and hydration group (p<0.05). 2. In urine alkalizing agent foup, diurnal urinary pH of sodium bicarbicar-bonate groups (4gm./day, 6gm./day, 8gm./day and 12gm./day) were 6.26+0.51, 6.64+0.41, 6.74+0.53 and 7. 15+0.64 respectively, and diurnal urinary pH of citrate agent foups (Eisenberg`s solution and CG-120) were 7.04+0.78 and 6.48+0.60 respectively. The urinary pH was increased about 0.1 every 1gm./day addition of sodium bicarbonate. For maintenance of urinary pH between 6.2-7.0 administration 4-8gm./day of sodium bicarbonate was favorable. It was 5 times as much as CG-120 (4gm./day) in amount that Eisenberg`s solution contains 19.12gm of citrate in diurnal administration volume (60cc/day). So the augment effect of urinary pH of CG-120 was significantly great and its side effect was relatively less.