Exp Neurobiol.  2014 Mar;23(1):45-52. 10.5607/en.2014.23.1.45.

Alzheimer's Disease and Stem Cell Therapy

• Choi SS
• Lee SR
• Kim SU
• Lee HJ

• KMID: 2009024
• DOI: http://doi.org/10.5607/en.2014.23.1.45

Abstract

The loss of neuronal cells in the central nervous system may occur in many neurodegenerative diseases. Alzheimer's disease is a common senile disease in people over 65 years, and it causes impairment characterized by the decline of mental function, including memory loss and cognitive impairment, and affects the quality of life of patients. However, the current therapeutic strategies against AD are only to relieve symptoms, but not to cure it. Because there are only a few therapeutic strategies against Alzheimer's disease, we need to understand the pathogenesis of this disease. Cell therapy may be a powerful tool for the treatment of Alzheimer's disease. This review will discuss the characteristics of Alzheimer's disease and various available therapeutic strategies.

Keyword

Alzheimer's disease; stem cell-gene therapy; transplantation

MeSH Terms

Alzheimer Disease*
Cell- and Tissue-Based Therapy
Central Nervous System
Humans
Memory Disorders
Neurodegenerative Diseases
Neurons
Quality of Life
Stem Cells*
Transplantation