J Korean Diabetes Assoc.  2004 Feb;28(1):45-50.

A Case of Primary Insulin Autoimmune Syndrome in a Patient Suspected of Having an Insulinoma

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Insulin autoimmune syndrome consists of fasting hypoglycemia, hyperinsulinemia and detectable insulin-binding antibodies in patients never been exposed to exogenous insulin. Most affected patients present with other autoimmune disorders, most often Graves' disease. A significant increase in the insulin and C-peptide plasma concentrations and the presence of other anti organ antibodies are also observed. Awareness of insulin autoimmune syndrome hypoglycemia is important as this may produce severe neuroglycopenic symptoms, which may be confused with the presence of an insulinoma. The correct diagnosis is important to avoid unnecessary surgical intervention in patients who are best treated with conservative support, watchful waiting, or in some cases, immunosuppressive therapy. Herein, a case of autoimmune insulin syndrome, suspected as being an insulinoma is reported.

Keyword

Insulin autoimmune syndrome; Insulinoma; Hypoglycemia

MeSH Terms

Antibodies
C-Peptide
Diagnosis
Graves Disease
Humans
Hyperinsulinism
Hypoglycemia
Insulin*
Insulinoma*
Plasma
Watchful Waiting
Antibodies
C-Peptide
Insulin
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