J Korean Soc Radiol.  2013 Nov;69(5):377-384. 10.3348/jksr.2013.69.5.377.

Factors Influencing Liver and Spleen Volume Changes after Donor Hepatectomy for Living Donor Liver Transplantation

• Bae JH
• Ryeom H
• Song JH

• KMID: 2002859
• DOI: http://doi.org/10.3348/jksr.2013.69.5.377

Abstract

PURPOSE
To define the changes in liver and spleen volumes in the early postoperative period after partial liver donation for living-donor liver transplantation (LDLT) and to determine factors that influence liver and spleen volume changes.
MATERIALS AND METHODS
27 donors who underwent partial hepatectomy for LDLT were included in this study. The rates of liver and spleen volume change, measured with CT volumetry, were correlated with several factors. The analyzed factors included the indocyanine green (ICG) retention rate at 15 minutes after ICG administration, preoperative platelet count, preoperative liver and splenic volumes, resected liver volume, resected-to-whole liver volume ratio (LV(R)/LV(W)), resected liver volume to the sum of whole liver and spleen volume ratio [LV(R)/(LV(W) + SV(0))], and pre and post hepatectomy portal venous pressures.
RESULTS
In all hepatectomy donors, the volumes of the remnant liver and spleen were increased (increased rates, 59.5 +/- 50.5%, 47.9 +/- 22.6%). The increment rate of the remnant liver volume revealed a positive correlation with LV(R)/LV(W) (r = 0.759, p < 0.01). The other analyzed factors showed no correlation with changes in liver and spleen volumes.
CONCLUSION
The spleen and remnant liver volumes were increased at CT volumetry performed 2 weeks after partial liver donation. Among the various analyzed factors, LV(R)/LV(W) influences the increment rate of the remnant liver volume.

MeSH Terms

Hepatectomy*
Humans
Indocyanine Green
Liver Transplantation*
Liver*
Living Donors*
Platelet Count
Postoperative Period
Spleen*
Tissue Donors*
Indocyanine Green