J Korean Acad Rehabil Med.  2004 Oct;28(5):412-417.

Influence of Lesion Location on Cortical Recovery Pattern in Hemiparetic Stroke Patients

• Jang SH
• Son SM
• Ahn SH
• Cho SH
• Jang HW
• Cho YW
• Yang DS
• Lee DG

Abstract

OBJECTIVE
The aim of this study was to elucidate how the location of cerebral infarct influences cortical recovery pattern in hemiparetic stroke patients. METHOD: Forty-three chronic stroke patients and 21 control subjects were recruited for the study. The patients were classified into 4 groups according to infarct locations: cortex (CO), corona radiata (CR), posterior limb of the internal capsule (PL), and brainstem (BS). Functional MRI was performed using the blood oxygen level-dependent technique at 1.5 T with the motor task of hand grasp-release movements. RESULTS: The activation pattern of the primary sensori-motor cortex (SM1) was found to be significantly influenced by the lesion locations, but that of the secondary motor area was not (Pearson's chi-square test, p<0.05). The contralateral' SM1 activation was the major response in the control group (85.7%) and in the BS group (75.0%). On the other hand, the major activation pattern was `peri-lesional' in the CO group (peri-lesional 57.1%, peri-lesional and ipsilateral 42.9%), `bilateral activation' in the CR (85.7%) and the PL group (100.0%). CONCLUSION: Our results suggested that motor recovery mechanisms could be different according to location of cerebral infarct.

Keyword

Functional magnetic resonance imaging; Stroke; Motor recovery; Hemiplegia

MeSH Terms

Brain Stem
Extremities
Hand
Hemiplegia
Humans
Internal Capsule
Magnetic Resonance Imaging
Oxygen
Stroke*
Oxygen