Korean J Nephrol.  2002 Nov;21(6):1020-1025.

A Case of Severe Rhabdomyolysis with Acute Renal Failure after Doxylamine Overdose

• Kim SR
• Lee HW
• Lee JY
• Ahn HL
• Jo YI
• Song JO

Abstract

Doxylamine succinate is an over-the-counter drug widely used for treating insomnia. We experienced a case of severe rhabdomyolysis complicating acute renal failure after doxylamine overdose in a 24-year- old male. The maximum values of creatine kinase and creatinine level during hospitalization were 264,141 IU/L and 8.4 mg/dL, respectively. Oliguria and severe dyspnea occurred on the sixth hospital day and were treated with hemodialysis. Then, he recovered without any sequelae. To the best of our knowledge, the maximum creatine kinase level of 264,141 IU/L in the present case is the highest value among the case reports on doxylamine-induced rhabdomyolysis and this is the first case report in Korea of doxylamine-induced severe rhabdomyolysis accompanying oliguric acute renal failure and requiring treatment with hemodialysis.

Keyword

Doxylamine; Rhabdomyolysis; Acute renal failure; Hemodialysis

MeSH Terms

Acute Kidney Injury*
Creatine Kinase
Creatinine
Doxylamine*
Dyspnea
Hospitalization
Humans
Korea
Male
Oliguria
Renal Dialysis
Rhabdomyolysis*
Sleep Initiation and Maintenance Disorders
Succinic Acid
Creatine Kinase
Creatinine
Doxylamine
Succinic Acid