Korean J Reprod Med.
2008 Jun;35(2):119-129.
Expression of Decidual Natural Killer (NK) Cells in Women of Recurrent Abortion with Increased Peripheral NK Cells
- Affiliations
-
- 1Lin Women's Hospital, Seoul, Korea.
- 2Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea. km2955@yahoo.co.kr
- 3Department of Pathology, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea.
- 4Department of Clinical Pathology, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea.
- 5Department of Obstetrics and Gynecology, Inje University, Sanggye Paik Hospital, Seoul, Korea.
Abstract
OBJECTIVE
The purpose of this study was to quantify decidual CD56+ and CD16+ NK cell subtype population and to evaluate the correlation between decidual NK cell expression and peripheral CD56+ NK cell expression in women with a history of recurrent abortion and increased peripheral NK cells.
METHODS
Twenty-nine women with recurrent abortion and elevated peripheral CD56+ NK cell percentage who had chromosomally normal conceptus were included in this study. Thirty-two women with recurrent abortion who had chromosomally abnormal conceptus were used as controls. Distribution of CD56+ and CD16+ NK cells in decidual tissues including implantation sites was examined by immunohistochemical staining. The degree of immunohistochemical staining was interpreted by score and percentage.
RESULTS
There was a significant difference in decidual CD56+ NK cell score (43.6+/-24.5 vs. 23.9+/-16.3 P =0.001) and CD56+ NK cell percentage (42.1+/-11.7 vs. 33.9+/-15.8 P =0.027) between increased peripheral NK cell group and control group. However, there was no statistically significant difference in decidual CD16+ NK cell score (18.7+/-9.5 vs. 13.2+/-39.4 P =0.108) and CD16+ NK cell percentage (24.7+/-5.9 vs. 23.4+/-11.7 P =0.599). There was no significant correlation between decidual NK cell score and peripheral NK cell percentage in increase peripheral NK cell group (peripheral CD56+ NK cell percentage vs. decidual CD56+ NK cell score, r=-0.016, P =0.932, peripheral CD16+ NK cell percentage vs. decidual CD16+ NK cell score, r=0.008, P =0.968).
CONCLUSION
This study shows that CD56+ decidual NK cells are increased in decidua of women exhibiting a history of recurrent abortion with increased CD56+ peripheral NK cell. There was no significant correlation between decidual and peripheral NK cell increment in increase peripheral NK cell group. This study suggests the possibility that decidual NK cells may play an important role in the immune mechanism of recurrent abortion.
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