Korean J Med.
2005 Mar;68(3):284-291.
Polymorphisms of interleukin-1beta and interleukin-1 receptor antagonist genes in patients with pulmonary tuberculosis
- Affiliations
-
- 1Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. yskimdr@yahoo.co.kr
- 2Department of Thoracic Surgery, Pusan National University College of Medicine, Busan, Korea.
- 3Pusan National University Hospital Medical Research Institute, Busan, Korea.
- 4Masan National Hospital, Masan, Korea.
Abstract
-
BACKGROUND: Several lines of evidence suggest that host genetic factors influence the outcome of exposure to Mycobacterium tuberculosis. The aim of this study was to determine whether polymorphisms in interleukin-1beta (IL-1beta) and Interleukin-1 receptor antagonist (IL-1Ra) genes associate with the susceptibility or resistance to pulmonary tuberculosis in Korean.
METHODS
IL-1beta and IL-1Ra gene polymorphism were investigated in 60 drug sensitive (DS) and 100 multidrug-resistant (MDR) pulmonary tuberculosis cases, and 96 healthy controls. IL-1beta-511/-31/+3954 and IL-1Ra genotype were determined by polymerase chain reaction.
RESULTS
Allelic and genotypic frequencies of IL-1beta-511/-31/+3954 showed no significant difference in 3 groups. IL-1Ra allele 2 heterozygotes were less frequent in DS (p=0.03, OR=0.26, 95% CI 0.07 to 0.95) and MDR tuberculosis (p=0.008, OR=0.26, 95% CI 0.09 to 0.75) than controls, but there was no significant difference between DS and MDR tuberculosis (p=1.00).
CONCLUSION
IL-1Ra allele 2 heterozygote may be associated with resistance to pulmonary tuberculosis in Korean. Further studies will be required to confirm whether these results are of biologic significance.
Keyword
MeSH Terms
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Relationship between spontaneous preterm birth and polymorphisms of Interleukin-1beta and Interleukin-1 receptor antagonist in Korean women
- Effects of B-16 Melanoma Cells and Mycoplasma pneumoniae on the Induction of IL-1 beta, IL-2, IL-6, IL-10, IL-12, and TNF - alpha from Mouse Astrocytes
- IL-1B-31 and IL-1Ra polymorphisms associated with increased host susceptibility to immune thrompocytopenia
- IL-1beta and IL-1 Receptor Antagonist Gene Polymorphisms in Myasthenia Gravis
- Polymorphisms of interleukin-1beta promoter in simple febrile seizures
