J Cardiovasc Ultrasound.
2011 Jun;19(2):95-98. 10.4250/jcu.2011.19.2.95.
Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome
- Affiliations
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- 1Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. choish@hallym.ac.kr
- 2Department of Hemato-Oncology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- KMID: 1980359
- DOI: http://doi.org/10.4250/jcu.2011.19.2.95
Abstract
- Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.
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