Korean J Pathol.  2009 Jun;43(3):279-284.

The Cytologic Features of Desmoplastic Small Round Cell Tumor with Intranuclear Inclusions : A Case Report

Affiliations
  • 1Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea. ojlee@chungbuk.ac.kr
  • 2Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm of young adults and it is characterized by polyphenotypic differentiation. We experienced a case of abdominal DSRCT that occurred in a 19-year-old female who presented with painful swelling of her right forearm. The tumor was cytokeratin-negative and it exhibited some tumor cells with intranuclear inclusions. Molecular demonstration of EWS-WT1 fusion transcripts is particularly useful to confirm the diagnosis of DSRCT without epithelial differentiation. We report here on a case of cytokeratin-negative DSRCT that showed an unusual feature of intranuclear inclusions.

Keyword

Desmoplastic small round cell tumor; Cytokeratin; EWS-WT1 fusion protein; Intranuclear Inclusions; Cytology

MeSH Terms

Desmoplastic Small Round Cell Tumor
Female
Forearm
Humans
Intranuclear Inclusion Bodies
Keratins
Young Adult
Keratins
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