Korean J Fam Med.  2014 May;35(3):143-151. 10.4082/kjfm.2014.35.3.143.

Association between Dyslipidemia and the Prevalence of Colon Polyps Based on a Health Evaluation of Subjects at a Hospital

• Kim YJ
• Lee KJ
• Park SY
• Han JH
• Kwon KY
• Kim JH

• KMID: 1978539
• DOI: http://doi.org/10.4082/kjfm.2014.35.3.143

Abstract

BACKGROUND
Colonic neoplasm is associated with western diet intake and physical inactivity. These life styles are also risk factors for dyslipidemia and metabolic syndrome. The aim of this study was to evaluate the association between dyslipidemia and the prevalence of colon polyps including colon adenoma as a precancerous lesion of colonic neoplasms.
METHODS
We selected subjects undergoing a colonoscopy for health screening at the Health Promotion Center of Eulji General Hospital from January 2006 to June 2010. Subjects with histories of cancers, dyslipidemia treatment, and other intestinal diseases like Crohn's disease and ulcerative colitis were excluded. The total numbers of subjects included in the study was 605. Chi-square test and t-test and were used for the analysis. Additionally we used multivariate logistic regression to adjust for sex, age, smoking, drinking, and other risk factors.
RESULTS
The prevalence of colon polyps was 48.70% and 28.05% in males and females, respectively. When adjusting for variables that included age, body mass index, hypertension, diabetes mellitus, smoking, drinking, and exercise, dyslipidemia was not significantly associated with the prevalence of colon polyps. However upon analyzing adenomatous colon polyps in men, dyslipidemias due to triglycerides and high density lipoproteins were significant factors (odds ratio [OR], 2.13; confidence interval [CI], 1.14 to 3.98; OR, 2.24; CI, 1.15 to 4.34, respectively).
CONCLUSION
Dyslipidemia was not a significant factor in the prevalence of colon polyps. However it had a significant association with the prevalence of adenomatous colon polyps in men.

Keyword

Colonic Polyps; Serum Cholesterol; Dyslipidemias

MeSH Terms

Adenoma
Body Mass Index
Colitis, Ulcerative
Colon*
Colonic Neoplasms
Colonic Polyps
Colonoscopy
Crohn Disease
Diabetes Mellitus
Diet
Drinking
Dyslipidemias*
Female
Health Promotion
Hospitals, General
Humans
Hypertension
Intestinal Diseases
Life Style
Lipoproteins, HDL
Logistic Models
Male
Mass Screening
Polyps*
Prevalence*
Risk Factors
Smoke
Smoking
Triglycerides
Lipoproteins, HDL
Smoke
Triglycerides