Imaging Sci Dent.  2014 Mar;44(1):75-79. 10.5624/isd.2014.44.1.75.

Glandular odontogenic cyst: A case report

Affiliations
  • 1Department of Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai, India. shezt3@gmail.com
  • 2Department of Oral Pathology, Nair Hospital Dental College, Mumbai, India.

Abstract

Glandular odontogenic cysts (GOCs) are rare intrabony solitary or multiloculated cysts of odontogenic origin. The importance of GOCs lies in the fact that they exhibit a propensity for recurrence similar to keratocystic odontogenic tumors and that they may be confused microscopically with central mucoepidermoid carcinoma. Thus, the oral and maxillofacial radiologists play an important role in definitive diagnosis of GOC based on distinctive cases; though they are rare. In large part, this is due to the GOC's complex and frequently non-specific histopathology. This report describes a case of GOC occurrence in the posterior mandibular ramus region in a 17-year-old female, which is a rare combination of site, age, and gender for occurrence.

Keyword

Odontogenic Cysts; Panoramic Radiography; Cone-Beam Computed Tomography

MeSH Terms

Adolescent
Carcinoma, Mucoepidermoid
Cone-Beam Computed Tomography
Diagnosis
Female
Humans
Odontogenic Cysts*
Odontogenic Tumors
Radiography, Panoramic
Recurrence

Figure

  • Fig. 1 A panoramic radiograph shows a well-defined multiloculated radiolucent lesion extending from the distal border and apex of lower right second molar into the ramus till approximately 3 mm away from the sigmoid notch enclosing the developing tooth bud of right lower third molar.

  • Fig. 2 A. An axial CBCT image shows multiple curved bony septae (black arrows). B. A sagittal CBCT image shows scalloped borders of the cystic lesion (black arrows). C. A reconstructed panoramic CBCT image shows a well-defined radiolucent lesion in the right mandibular ramal region extending from the right lower second molar to the upper third of the ramus with resorption of the apex of the second molar (black arrow) and with well-defined sharp right angle septa (black arrow head). D. A coronal CBCT image shows perforation of the right lingual cortical plate (black arrow head) and thinning of the right buccal cortical plate (white arrow head).

  • Fig. 3 Histopathologic examination shows cystic lumen lined by pseudo-stratified columnar epithelium with filiform extensions of the cytoplasm and mucous-secreting cells with intra-epithelial spherule formation, characteristic of glandular odontogenic cyst (H&E stain, 400×).

  • Fig. 4 A panoramic radiograph shows healing of the surgical defect by new bone formation 3 months post-surgery (white arrow heads).


Cited by  1 articles

Glandular odontogenic cyst mimicking ameloblastoma in a 78-year-old female: A case report
Byung-Do Lee, Wan Lee, Kyung-Hwan Kwon, Moon-Ki Choi, Eun-Joo Choi, Jung-Hoon Yoon
Imaging Sci Dent. 2014;44(3):249-252.    doi: 10.5624/isd.2014.44.3.249.


Reference

1. Padayachee A, Van Wyk CW. Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo-odontogenic cyst? J Oral Pathol. 1987; 16:499–504.
Article
2. Gardner DG, Kessler HP, Morency R, Schaffner DL. The glandular odontogenic cyst: an apparent entity. J Oral Pathol. 1988; 17:359–366.
Article
3. Kramer IR, Pindborg JJ, Shear M. The WHO histological typing of odontogenic tumours: a commentary on the second edition. Cancer. 1992; 70:2988–2994.
4. Sadeghi EM, Weldon LL, Kwon PH, Sampson E. Mucoepidermoid odontogenic cyst. Int J Oral Maxillofac Surg. 1991; 20:142–143.
Article
5. High AS, Main DM, Khoo SP, Pedlar J, Hume WJ. The polymorphous odontogenic cyst. J Oral Pathol Med. 1996; 25:25–31.
Article
6. Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: a challenge in diagnosis and treatment. Oral Dis. 2008; 14:575–581.
Article
7. Guruprasad Y, Chauhan DS. Glandular odontogenic cyst of maxilla. J Clin Imaging Sci. 2011; 1:54.
Article
8. Nair RG, Varghese IV, Shameena PM, Sudha S. Glandular odontogenic cyst: report of a case and review of literature. J Oral Maxillofac Pathol. 2006; 10:20–23.
Article
9. Gardner DG, Morency R. The glandular odontogenic cyst, a rare lesion that tends to recur. J Can Dent Assoc. 1993; 59:929–930.
10. Krishnamurthy A, Sherlin HJ, Ramalingam K, Natesan A, Premkumar P, Ramani P, et al. Glandular odontogenic cyst: report of two cases and review of literature. Head Neck Pathol. 2009; 3:153–158.
Article
11. Manor R, Anavi Y, Kaplan I, Calderon S. Radiological features of glandular odontogenic cyst. Dentomaxillofac Radiol. 2003; 32:73–79.
Article
12. Brannon RB, Kessler HP, Castle JT, Kahn MA. Glandular odontogenic cyst: analysis of 46 cases with special emphasis on microscopic criteria for diagnosis. Head Neck Pathol. 2011; 5:364–375.
13. Prabhu S, Rekha K, Kumar G. Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma. J Oral Maxillofac Pathol. 2010; 14:12–15.
Article
14. Salehinejad J, Saghafi S, Zare-Mahmoodabadi R, Ghazi N, Kermani H. Glandular odontogenic cyst of the posterior maxilla. Arch Iran Med. 2011; 14:416–418.
15. Łuczak K, Nowak R, Rzeszutko M. Glandular odontogenic cyst of the mandible associated with impacted tooth: report of a case and review of literature. Dent Med Probl. 2007; 44:403–406.
16. Kaplan I, Anavi Y, Manor R, Sulkes J, Calderon S. The use of molecular markers as an aid in the diagnosis of glandular odontogenic cyst. Oral Oncol. 2005; 41:895–902.
Article
17. Noffke C, Raubenheimer EJ. The glandular odontogenic cyst: clinical and radiological features; review of the literature and report of nine cases. Dentomaxillofac Radiol. 2002; 31:333–338.
Article
18. MacDonald-Jankowski DS. Glandular odontogenic cyst: systematic review. Dentomaxillofac Radiol. 2010; 39:127–139.
Article
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