Cancer Res Treat.  2008 Dec;40(4):178-183.

Clinical Factors Related to Suspected Second Primary Lung Cancer Development in Patients with Head and Neck Cancer

• Kim EB
• Park Y
• Park SJ
• Kim DS
• Kim JW
• Seo HY
• Sung HJ
• Choi IK
• Park KH
• Oh SC
• Choi CW
• Kim BS
• Kim YH
• Kim JS
• Shin SW
• Kim CY
• Jung KY

Abstract

PURPOSE: The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC.
MATERIALS AND METHODS
We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006.
RESULTS
A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001).
CONCLUSIONS
Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.

Keyword

Chest x-ray; Head and neck neoplasms; Second primary cancer

MeSH Terms

Academic Medical Centers
Head
Head and Neck Neoplasms
Humans
Incidence
Korea
Lung
Lung Neoplasms
Male
Neoplasms, Second Primary
Retrospective Studies
Risk Factors
Thorax

Figure

• 

  Fig. 1 Kaplan Meier survival curves for primary HNC and second primary lung cancer patients. (A) The median survival curves for HNC only patients and second primary lung cancer patients. (B) The adjusted median survival curves for HNC only patients and second primary lung cancer patients.

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