Tuberc Respir Dis.  2006 Dec;61(6):573-577. 10.4046/trd.2006.61.6.573.

A Case of Pulmonary Metastasis of a Dermatofibrosarcoma Protuberans

• Jung SJ
• Byun MK
• Chung WY
• Park MS
• Kang SM
• Kim HR
• Shin DH
• Kim SK
• Chang J
• Kim SK
• Kim YS

• KMID: 1970243
• DOI: http://doi.org/10.4046/trd.2006.61.6.573

Abstract

Dermatofibrosarcoma protuberans (DFPS) is a locally aggressive skin tumor with a very low incidence in the general population. This tumor has a remarkable tendency to recur, However, a metastasis is rare. We report a case of DFPS with a pulmonary metastasis in 28-year-old man. The pulmonary metastasis developed 5 years after a complete resection of the primary skin tumor. We reviewed the clinical manifestations and treatment of DFPS, and highlight the need for a long-term follow-up examination for metastases after a wide excision of these lesions.

Keyword

Dermatofibrosarcoma protuberans; Pulmonary metastasis

MeSH Terms

Adult
Dermatofibrosarcoma*
Follow-Up Studies
Humans
Incidence
Isoflurophate
Neoplasm Metastasis*
Skin
Isoflurophate

Figure

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  Figure 1 A) Low-power magnification of the right flank mass shows a solid cellular tumor with infiltrative borders and arranged in short fascicles (Original magnification ×40; Hematoxylin-eosin). B) The tumor cells show plump spindle-shaped nuclei and indistinct cytoplasmic borders (Original magnification ×200; Hematoxylin-eosin).

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  Figure 2 A) Chest PA shows about 4 × 5 cm sized lobulated well-defined mass at left lower lobe. B) Chest CT shows a 4.4cm × 2.6cm sized mass at the anterior basal segment of left lower lobe.

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  Figure 3 Whole body Positron emission and computed tomography(PET-CT) scan shows mass lesion with FDG uptake with moderate degree at left lower lobe. It was compatible with metastasis of soft tissue sarcoma with intermediate grade.

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  Figure 4 A) The metastasis tumor is relatively well-demarcated, and shows short fascicular arrangement similar to the pattern seen in the primary tumor (Original magnification ×100; Hematoxylin-eosin). B) Immunohistochemical stain shows strong cytoplasmic expression of CD34 in the tumor cells (Original magnification ×400).

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