J Korean Assoc Maxillofac Plast Reconstr Surg.
2012 May;34(3):163-172.
Effect of Low-Intensity Pulsed Ultrasound on Bone Healing around Titanium Implant in Tibia of Diabetes Mellitus Induced Rats
- Affiliations
-
- 1Department of Oral and Maxillofacial Surgery, Pusan National University School of Dentistry, Korea. kuksjs@pusan.ac.kr
- 2Department of Oral and Maxillofacial Surgery, Busan Paik Hospital, Inje University College of Medicine, Korea.
- 3Department of Oral and Maxillofacial Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Korea.
Abstract
- PURPOSE
Diabetes mellitus (DM) has been shown to alter the properties of the bone and impair bone healing around a titanium implant. The aim of this study is to investigate whether the low-intensity pulsed ultrasound (LIPUS), which has been known to stimulate the bone healing, improve the osseointegration of the titanium implant in tibia of DM-induced rats.
METHODS
16 rats were received streptozotocin (60 mg/kg) for inducing diabetes. A total number of 32 titanium implants were placed bilaterally into both tibiae of these rats. The right tibia of each rat received LIPUS application (10 min/day) during 7 days post-operation, while the left side received no treatment. The study was carried on for six weeks and the rats were sacrificed at 1, 2, 4, and 6 weaks postoperatively (4 rats for each week) for histomorphometric and histologic analysis. Bone-implant contact and bone area were measured. Comparisons between the groups were made using statistical analysis on histomorphometric analysis.
RESULTS
The histomorphometry parameters showed that the bone-implant contact and the bone area values have decreased in the late osseointegration periods (4, 6 weeks) compared to the early osseointegration periods (1, 2 weeks) in both two groups. The bone-implant contact values of the LIPUS group were somewhat higher than those of controls at 1, 2 weeks, but the difference was not statistically significant. The bone area values of the LIPUS group were also higher than those of controls at 1, 2 weeks, but the difference was not statistically significant as well.
CONCLUSION
Results of this study indicate that LIPUS may have positive effects on early osseointegration but could not improve the long term stability of dental implants.
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