Keimyung Med J.  2014 Dec;33(2):152-158. 10.0000/kmj.2014.33.2.152.

Effect of Isotretionin for Refractory Solid-pseudopapillary Tumor of the Pancreas which Previously did not Respond to Anticancer Drugs and Radiation Therapy

• Kim YJ
• Ahn YJ
• Lee HJ
• Jung HR
• Kim OB
• Won KS
• Kim JY
• Kim HS

• KMID: 1967204
• DOI: http://doi.org/10.0000/kmj.2014.33.2.152

Abstract

Solid pseudopapillary neoplasm (SPN) of the pancreas is an exocrine tumor with low malignant nature. Although it's treatment of choice is complete surgical resection, the patients who are not eligible for surgical therapy need other kinds of therapy and there are little reports. Vitamin A and its derivatives in some tumors are known to be prohibiting the tumors' growth by reducing the manifestation of transcription factors. We present one case of SPN of the pancreas, which was not eligible for resection and was not responding to chemotherapy and radiation therapy, but, responded with the administration of Isotretionin (Roaccutan(R)). Therefore, for inoperable SPN of the pancreas, we consider Isotretionin therapy can be used as treatment and, in the future, new studies with more of Isotretionin treatment implemented cases should be conducted to identify their anticancer mechanism.

Keyword

Isotretionin; Solid-pseudopapillary neoplasm of the pancreas; Treatment

MeSH Terms

Drug Therapy
Humans
Pancreas*
Transcription Factors
Vitamin A
Transcription Factors
Vitamin A