J Korean Neurol Assoc.  2011 Nov;29(4):347-351.

Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement

• Chung DI
• Oh SI
• Oh KP
• Baek W
• Kim HJ
• Kim SH

Abstract

Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography.

Keyword

Progressive multifocal leukoencephalopathy; Magnetic resonance spectroscopy; Tractography

MeSH Terms

Cytarabine
Cytosine
Demyelinating Diseases
Follow-Up Studies
Humans
Leukoencephalopathy, Progressive Multifocal
Magnetic Resonance Spectroscopy
Neuroimaging
Organophosphonates
Regeneration
Cytarabine
Cytosine
Organophosphonates