J Korean Neurol Assoc.  2011 Nov;29(4):332-334.

Intracranial Langerhans Cell Histiocytosis Presenting with Dysarthria and Gait Disturbance

• You CG
• Lee EJ
• Ryu HS
• Hwang JH
• Kim BM
• Chung SJ

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system involving clonal proliferation of Langerhans cells. Central nervous system (CNS) involvement of LCH occurs in 10-57% of all LCH cases. This disease is known to present in two ways in the CNS: intracranial tumorous lesions or intracranial nontumorous lesions (neurodegeneration). We report here an LCH patient who developed gait disturbance and dysarthria due to neurodegenerative lesions associated with LCH.

Keyword

Langerhans cell histiocytosis; Neurodegenerative lesion

MeSH Terms

Central Nervous System
Dysarthria
Gait
Histiocytosis, Langerhans-Cell
Humans
Langerhans Cells
Rare Diseases